Johnston Lab
​Computations in Neural Circuits

Computations in Neural Circuits

We are interested in how the external world is represented by the brain. To address this question we focus on how sensory information is transformed by neural circuits in the early sensory pathways. What computations do these circuits perform and how they are implemented by the neural hardware? 
Exploring Neural Circuits
Some examples of the methods we employ to interrogate neural circuits
Multi-photon imaging: An array of retinal bipolar cell terminals responding to a moving bar. Data acquired by in vivo multi-photon imaging of zebrafish retina expressing SyGCaMP6 in all retinal bipolar cells
Electrophysiology: Paired recording of mitral-mitral cell synapses in the main olfactory bulb
Optogenetics: An image stack through the glomerular layer of a mouse expressing YFP-tagged Channelrhodopsin-2
Computational modeling: A realistic model of a retinal ganglion cell and the excitatory and inhibitory synapses of the inner plexiform layer of the retina